Lub ntsiab lus ntawm NAD yog dab tsi?
NAD yog lub npe luv ntawm nicotinamide adenine dinucleotide, tseem paub tias yog Coenzyme I. Nws yog ib qho tseem ceeb ntawm coenzyme hauv peb lub cev uas xav tau los hloov cov electrons. Hauv cov tshuaj metabolic ntawm peb cov hlwb, nicotinamide adenine dinucleotide feem ntau koom nrog hauv coenzyme.
NAD los ntawm ob hom: NAD + (daim ntawv oxidized) thiab NADH (txo daim ntawv). NAD + yog ib qho tseem ceeb coenzyme pom nyob rau hauv tag nrho cov hlwb nyob. Nws koom nrog hauv cov tshuaj tiv thaiv redox hauv cov hlwb thiab yog cov khoom tseem ceeb hauv cov txheej txheem metabolism hauv lub zog. Nws yog lub npe hu ua "lub zog txiaj" ntawm lub neej.
Lub luag haujlwm tseem ceeb ntawm NAD yog dab tsi?
1. Kev hloov hluav taws xob
NAD Nicotinamide Adenine Dinucleotideplays lub luag haujlwm tseem ceeb hauv cov txheej txheem ua pa ntawm tes, pab hloov cov khoom noj xws li qab zib rau hauv ATP, lub cell lub zog. Hauv cov txheej txheem no, NAD + lees txais thiab hloov hluav taws xob thiab koom nrog cov tshuaj tiv thaiv redox.
2. Kev cai ntawm cov noob qhia
Nws kuj ua hauj lwm raws li ib tug cofactor rau ntau yam enzymes thiab koom nyob rau hauv cov kev cai ntawm noob qhia. Piv txwv li, sirtuins (ib hom NAD+-dependent deacetylase) tswj hwm cov protein ua haujlwm los ntawm kev noj NAD +, yog li cuam tshuam rau cov txheej txheem physiological xws li cell aging, metabolism, thiab kev ntxhov siab.
3. Cell signaling
NAD + kuj tseem koom nrog hauv cov txheej txheem kev hloov pauv ntawm cov teeb liab intracellular, tswj kev loj hlob ntawm tes, kev sib txawv, apoptosis thiab lwm yam kev ua haujlwm hauv lub neej los ntawm kev cuam tshuam rau kev ua haujlwm ntawm cov teeb liab molecules xws li calcium ion channels thiab cyclic adenosine monophosphate (cAMP).
4. Txhim kho cellular aging
Kev tshawb fawb nyob rau hauv xyoo tas los no tau pom tias NAD + qib qhia txog kev poob qis thaum lub sij hawm cellular aging, thiab cov supplementation ntawm NAD + thiab nws cov precursors qhia tau hais tias zoo daim ntawv thov kev cia siab nyob rau hauv kev tiv thaiv thiab kev kho mob ntawm cov laus-txog kab mob. Kev tshawb fawb qhia tau hais tias kev laus, oxidative kev nyuaj siab thiab DNA puas tuaj yeem ua rau txo qis hauv cov ntaub so ntswg NAD + qib, thiab qhov txo qis ntawm NAD + qib tuaj yeem ua rau cov lus hais saum toj no. Yog li, txo qis NAD + qib yog ob qho tib si qhov tshwm sim ntawm cellular senescence thiab ua rau muaj kev cuam tshuam rau kev laus ntawm cov cellular dysfunction.
5. Kev tshawb fawb txog kev tiv thaiv myocardial
Cox et al. Ua ntej tau lees paub tias NAD + cuam tshuam rau cov txheej txheem mitochondrial redox, txhim kho lub zog metabolism, thiab yog li txhim kho plawv diastolic muaj nuj nqi. Hauv kev ua tsis tiav tib neeg thiab tsiaj lub siab, mitochondrial proteins tau pom tias muaj acetylated heev, uas cuam tshuam rau lub zog metabolism. Ntxiv NAD + kom nce SIRT3 kev ua ub no tuaj yeem txo qis acetylation thiab txhim kho lub plawv ua haujlwm.
6. Lub luag haujlwm ntawm NAD + hauv cov kab mob neurodegenerative
Cov kev tshawb fawb tshawb fawb tau pom tias hauv cov kab mob neurodegenerative, NAD +, cov enzymes tseem ceeb NAMPT, NADP +, thiab cov synthase NADK tuaj yeem tiv taus oxidative kev nyuaj siab thiab ua lub luag haujlwm tiv thaiv neuroprotective; NADH thiab NADPH tuaj yeem tiv taus oxidation thiab kho oxidation. Kev ntxhov siab plays ob lub luag haujlwm. Peb tuaj yeem pib nrog NAMPT thiab NADK, ob lub enzymes tseem ceeb, los cuam tshuam cov kab mob neurodegenerative.
7. NAD + ua lub luag haujlwm tseem ceeb hauv kev tswj cov metabolism thiab circadian rhythms
Lub luag haujlwm tseem ceeb ntawm NAD + yog los txhawb kev hloov pauv hydrogen hauv cov txheej txheem metabolic tseem ceeb. Hauv kev sim, NAD + tau hloov mus rau NADH los ntawm plaub theem ntawm mitochondrial TCA voj voog, uas acetyl-CoA yog oxidized rau carbon dioxide. NAD + kuj hloov mus rau NADH thaum lub sijhawm oxidation ntawm fatty acids thiab amino acids hauv mitochondria. Nyob rau hauv cov mitochondrial txoj kev, NADH tsim yog lub electron pub rau oxidative acidification thiab ATP synthesis.
Dab tsi yog qhov txawv ntawm NAD + thiab NADH?
NAD los ntawm ob hom: NAD + (daim ntawv oxidized) thiab NADH (txo daim ntawv)
Tom qab NADH tau noj, nws tuaj yeem ncaj qha decomposed rau hauv NAD + thiab lom hydrogen "H +" hauv lub cev, thiab tso tawm lub zog ATP, uas tsis tsuas yog nce qib ntawm NAD + hauv lub cev, tab sis kuj muab lub zog rau cov hlwb, thiab tib yam. lub sij hawm daws ob qhov teeb meem tseem ceeb tshaj plaws hauv kev tshawb fawb kev laus niaj hnub no.
Raws liNAD Nicotinamide Adenine Dinucleotidecov tuam txhab, LonierHerb tau paub txog cov txheej txheem tsim khoom, txhua xyoo, muaj ntau yam khoom xa tuaj thoob ntiaj teb. Yog tias koj txaus siab, thov hu rau peb dawb. Email:info@lonierherb.comWhatsapp / Wechat: +86-18189137076
