Dab tsi yog cov txiaj ntsig ntawm Stachydrine Hydrochloride?

Stachydrine hydrochloride yog lub teeb daj lossis dawb crystalline hmoov. Nws yooj yim soluble hauv dej thiab cawv, dilute acid, insoluble hauv ether thiab chloroform. Nws tuaj yeem ua rau kom cov ntshav txaus ntawm cov hlab ntsha ntawm cov hlab ntsha thiab myocardium, txo cov myocardial cell necrosis, txo cov vascular kuj, txhim kho microcirculation, ua kom lub plawv dhia qeeb, txo cov ntshav siab, thiab lwm yam. Nws muaj cov txiaj ntsig ntawm expectoration, antitussive, thiab so. ntawm bronchial smooth nqaij. Yog li ntawd, nws yog dav siv nyob rau hauv cov teb ntawm cov tshuaj, cov khoom kho mob, thiab tshuaj pleev ib ce.

1. Cov teebmeem ntawm lub tsev menyuam

Stahydrine muaj cov nyhuv contractile ntawm uterine kev ua haujlwm, thiab tuaj yeem cog lus rau lub tsev menyuam uas raug rho tawm.

Siv {{0}}.12 thiab 0.18 g·mL ntawm stachydrine hydrochloride los ua rau ntawm lub tsev menyuam ntawm cov nas uas muaj oxytocin-induced spasm tuaj yeem ua rau kom muaj zog ntau zaus thiab amplitude. Nyob rau tib lub sijhawm, nws muaj cov txiaj ntsig ntawm kev txo qis ntshav tom qab yug me nyuam thiab txhawb kev kho uterine hauv tsev menyuam tom qab rho menyuam. Siv cov khoom sib xyaw ua ke stachydrine 0.009, 0.018, 0.036 g·kg kom muab cov tshuaj mifepristone ntxiv rau misoprostol los ua kom lub cev ua haujlwm los ntshav hauv cov nas tuaj yeem txo cov ntshav uterine tom qab rho menyuam. Cov txheej txheem muaj feem xyuam rau kev txo cov ntsiab lus ntawm nitric oxide (NO) nyob rau hauv lub tsev menyuam cov leeg nqaij ntawm tus qauv nas thiab ua kom cov ntsiab lus ntawm endothelin (ET), vasoconstrictor yam nyob rau hauv lub uterine smooth nqaij, yog li txhawb kev kho cov ntaub so ntswg endometrial. Cov tshuaj tua cov nas rho menyuam tau muab tshuaj nrog mifepristone RU486 ntawm 2.5, 5, thiab 10 mg kg ntawm stachydrine hydrochloride. Cov txiaj ntsig tau pom tias cov ntshav uterine tau txo qis. Cov txheej txheem muaj feem xyuam rau kev tswj hwm cov protein qhia ntawm interleukin -12 (IL-12) thiab interleukin-6 (IL-6), txhawb kev qhia ntawm Th1 lymphocyte-specific transcription factor (T-tus thawj koom ruam) thiab retinoic acid receptor-related orphan receptor, thiab inhibiting mＲNA qhia ntawm GATA junction protein (GATA-33) thiab forkhead protein 3 (Foxp3).

2. Anti-inflammatory thiab anti-endotoxin

Nws muaj qhov pom tseeb los tiv thaiv kab mob thiab tshuaj tiv thaiv endotoxin.

Granuloma-induced nas tau muab 24 thiab 12 mg·kg ntawm stachydrine los ntawm gavage nrog paj rwb rau 7 hnub sib law liag. Cov txiaj ntsig tau pom tias qhov loj ntawm granuloma tau txo qis, nrog rau inhibition ntawm 35.04% thiab 26.55%, feem. Pleurisy nas tau muab 24 thiab 12 mg·kg ntawm stachydrine los ntawm gavage nrog carrageenan rau 7 hnub. Cov txiaj ntsig tau pom tias qhov ntim ntawm pleural effusion hauv nas tau txo qis, thiab cov theem ntawm inflammatory yam xws li prostaglandin E2 (PGE2), IL-1, thiab qog necrosis factor- (TNF-) hauv pleural effusion ntawm nas raug txo. Nyob rau tib lub sijhawm, stachydrine 32, 16, thiab 9 mg·kg tau muab rau cov nas ib txwm siv los ntawm gavage rau 7 hnub sib law liag, uas tuaj yeem txo qhov o ntawm pob ntseg ntawm nas vim xylene, nrog inhibition ntawm 36.84% thiab 27.63. %, feem. Tus qauv ICR nas kev sib tw tau raug ntxias los ntawm kev txhaj tshuaj intraperitoneal ntawm cov kab mob endotoxin (LPS) nrog 10 mg·kg stachydrine. Cov txiaj ntsig tau pom tias cov qauv nas tau nce qhov hnyav, txo qis cov plab hnyuv siab, thiab txhim kho txoj hnyuv pathological puas tsuaj.

3. cuam tshuam rau cov ntshav

1) Tiv thaiv vascular endothelial hlwb

Tus qauv endothelial cell (EC) raug mob los ntawm 1 mg·L LPS tau cuam tshuam los ntawm 1, 5, thiab 1{{20}} mg·L stachydrine. Nws tau pom tias stachydrine tuaj yeem cuam tshuam qhov tso tawm ntawm thromboxane B2 (TXB2) los ntawm cov hlwb endothelial. Kev tswj hwm ntawm 1 × 10-8, 1 × 10-7, 1 × 10-6, thiab 1 × 10-5 mol·L ntawm stachydrine rau hypoxia-reoxygenation-induced human umbilical vein endothelial cell (HUVEC) raug mob qauv thim rov qab endothelial cell viability thiab cov dej num ntawm superoxide dismutase (SOD) thiab glutathione peroxidase (GSH-Px), txo cov lactate dehydrogenase (LDH), malondialdehyde (MDA) cov ntsiab lus thiab ET-1 qhia qib, thiab inhibited qhov kev qhia ntawm cov ntaub so ntswg (TF) ntawm mＲNA thiab protein ntau. Cov kab mob endothelial CPAE, CCL-209 aging qauv tshwm sim los ntawm 30 mmol·L qabzib tau cuam tshuam los ntawm 0.1 mmol·L stachydrine rau 48 teev, thiab cov hlwb endothelial feem ntau nyob hauv theem G0 / G1. Nws cov txheej txheem tiv thaiv kab mob endothelial muaj feem cuam tshuam rau nws qhov txo qis ntawm kev qhia ntau yam qog nqaij hlav qog p16INK4a thiab cov ntaub so ntswg sirtuin{27}} (SIＲT1). Kev tiv thaiv kev ua haujlwm ntawm stachydrine ntawm vascular endothelial hlwb yuav yog ib qho tseem ceeb ntawm kev txo qis ntshav qab zib.

2) Anticoagulation thiab vasodilation

Stahydrine muaj cov nyhuv anticoagulant thiab antiplatelet aggregation. Cov nas uas txias qi stagnation thiab ntshav stasis tau muab cov khoom siv hluavtaws stachydrine {{{0}}}009, 0.018, 0.036 g·kg los ntawm gavage nrog adrenaline ua ke nrog dej khov dej txias da dej rau 7 sib law liag. hnub. Cov txiaj ntsig tau pom tias lub sijhawm prothrombin (PT) thiab qhib lub sijhawm thromboplastin ib nrab (APTT) tau ntev heev, thaum qib TXB2 tau txo qis thiab qhov piv ntawm 6-keto-prostaglandin F1 (6-Keto- PGF1) to TXB

4. Kev cuam tshuam rau lub raum

1) Diuresis

Gavage ntawm 25 mg·kg stachydrine rau cov nas ib txwm pom tias muaj qhov tso zis ntau ntxiv, mus txog qhov siab tshaj hauv 2 teev. Urinalysis tau pom tias cov txiaj ntsig tseem ceeb yog ua kom cov pa tawm ntawm Na + thiab txo cov excretion ntawm K +. Tsis tas li ntawd, qhov excretion ntawm Cl- kuj tau nce.

2) Tiv thaiv raum

Nws muaj cov nyhuv anti-apoptotic rau lub raum tubular epithelial hlwb. Cov nas uas muaj lub raum interstitial fibrosis tshwm sim los ntawm unilateral ureteral obstruction tau muab stachydrine 93, 46, 23 mg kg rau 14 hnub sib law liag. Cov txiaj ntsig tau pom tias nws tuaj yeem txo qhov kev raug mob ntawm tubular Performance index ntawm cov qauv nas thiab txo cov qib ntawm lub raum interstitial fibrosis. Cov txheej txheem tau hais txog kev txhawb nqa ntawm kev qhia ntawm endoplasmic reticulum stress proteins GＲP78 thiab GＲP94 hauv nas raum cov ntaub so ntswg. Txoj kev tshawb nrhiav pom tias stachydrine tuaj yeem txo qis qhov kev raug mob ntawm tubular interstitial kev raug mob Performance index, ntshav creatinine thiab urea nitrogen ntau hauv cov nas uas muaj unilateral ureteral obstruction. Cov txheej txheem tau hais txog kev txo qis kev ua kom Caspase-12 thiab Caspase-9 hauv txoj kev apoptosis kho los ntawm lub raum hlwb. Tus qauv nas ntawm lub raum tsis ua haujlwm ntev tshwm sim los ntawm adenine (200 mg kg) tau kho nrog astragalus polysaccharide (400 mg·kg) thiab stachydrine (5 mg·kg) rau 7 lub lis piam sib law liag. Cov txiaj ntsig tau pom tias kev sib xyaw ntawm astragalus polysaccharide thiab stachydrine tuaj yeem txo qhov hnyav ntawm cov qauv nas, txo qis lub raum Performance index, txo cov ntshav creatinine thiab urea nitrogen, thiab txo qis kev qhia ntawm Cx40 thiab Cx45 hauv lub raum cov ntaub so ntswg. Tus qauv ntawm lub raum tubular epithelial cell (NRK52E) raug mob los ntawm hydrogen peroxide (H2O2) tau kho nrog stachydrine hydrochloride 14.04, 28.08, 42.12 mg·L rau 24 teev. Cov txiaj ntsig tau pom tias 14.04 mg·L stachydrine hydrochloride tuaj yeem txo cov apoptosis ntawm lub raum tubular epithelial hlwb los ntawm kev txhawb nqa kev qhia ntawm Bcl -2 protein.

5. Cov teebmeem ntawm cov hlab plawv

1) Anti-myocardial ischemia

Tus qauv nas ntawm tus mob myocardial ischemia-reperfusion tshwm sim los ntawm cov hlab ntsha tawg tau raug ntxias los ntawm tus Tsov tus tw leeg txhaj tshuaj ntawm 3, 6, thiab 12 mg·kg ntawm stachydrine. Cov txiaj ntsig tau pom tias tsis pub dhau 145 feeb tom qab kev tswj hwm, cov ntshav LDH, creatine kinase (CK) kev ua haujlwm, troponin (TcTnT), thiab MDA cov ntsiab lus ntawm cov qauv nas tau txo qis, thiab SOD kev ua haujlwm thiab NO qib tau nce. Cov nas uas mob myocardial ischemia tshwm sim los ntawm kev txhaj tshuaj subcutaneous ntawm 20 mg·kg ntawm isoproterenol tau muab 5 thiab 10 mg·kg ntawm stachydrine rau 7 hnub sib law liag. Cov txiaj ntsig tau pom tias qhov txawv txav T yoj hauv electrocardiogram raug txo qis, LDH kev ua haujlwm hauv cov ntshav ntawm cov nas raug txo, thiab qib ntawm kev puas tsuaj ntawm cov ntaub so ntswg myocardial tau txo qis, tab sis qee qhov myocardial fiber ntau contraction thiab rupture tseem pom.

2) Tiv thaiv cardiomyocytes

Nws ua rau tus qauv ntawm cov nas neonatal cardiomyocyte hypertrophy tshwm sim los ntawm norepinephrine (NE). Cov txiaj ntsig tau pom tias stachydrine txo qis thaj tsam ntawm cardiomyocytes, txo qis cov ntsiab lus ntawm cov protein ntawm cardiomyocytes, txo cov protein / DNA, txhim kho calcium uptake peev xwm ntawm sarcoplasmic reticulum ntawm myocardial mast cells thiab kev ua haujlwm ntawm cov leeg nqaij endoplasmic reticulum calcium triphosphatase ( SERCA), thiab txo cov ntsiab lus ntawm intracellular endothelial natriuretic peptide (ANP) thiab hlwb natriuretic peptide (BNP).

6. Antioxidant

Stachydrine hydrochloridemuaj cov teebmeem antioxidant. Tus qauv nas pleurisy raug ntxias los ntawm qhov ncauj tswj hwm ntawm carrageenan nrog stachydrine 24 thiab 12 mg·kg. Cov txiaj ntsig tau pom tias nws tuaj yeem txo qis MDA cov ntsiab lus hauv cov kua dej ntawm cov qauv nas thiab ua kom cov ntshav qab zib SOD nce ntxiv. Tus mob myocardial ischemia qauv nas tshwm sim los ntawm kev txhaj tshuaj subcutaneous ntawm isoproterenol 20 mg·kg nrog stachydrine 5 thiab 10 mg·kg tau kawm rau 7 hnub sib law liag. Nws tau pom tias txhua pawg koob tshuaj tuaj yeem txo qis MDA cov ntsiab lus hauv cov ntshav ntawm cov nas.

Peb yogStachydrine Hydrochlorideneeg tsim khoom. Txhua pawg ntawm cov khoom tuaj yeem xa tuaj rau koj tom qab kev tshuaj xyuas nruj. Yog xav paub ntxiv, thov hu rau thiab nug peb tam sim ntawd, koj qhov kev txaus siab yog peb qhov tseem ceeb tshaj plaws. Ua tsaug!

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