Puas yog madecassic acid muaj antioxidant thaj chaw?

Madecassic acidyog pentacthClic triterpenoid feem ntau pom nyob rau hauv centella asiatica (gotu kola). Nws tau txais kev tshawb fawb txog nws txoj kev sib txawv, tshwj xeeb yog nws cov khoom tiv thaiv antioxidant. Raws li oxidative kev ntxhov siab yog muab rau hauv ntau cov kab mob uas muaj mob ntev thiab kev laus, tej thaj teb sib xyaw nrog antioxidant muaj txiaj ntsig rau kev kho mob thiab cov ntawv thov kho. Cov ntawv no tshawb txog kev nkag siab txog science ntawm Madecassic acid `s antioxidant cov khoom, kev siv tshuab, thiab cov ntawv thov yuav.

Direct Dawb Radical Scavenging

Madecassic acid muaj ntau yam reasy oxygen hom (Ros) uas tuaj yeem ua rau cov khoom siv cellular. Nws cov qauv tshuaj, tshwj xeeb yog cov pab pawg hydroxyl, tso cai rau cov pab pawg hydrodogen rau cov lipids oxidative kev puas tsuaj rau lipids, cov protein, thiab DNA. Hauv cov kev tshawb fawb vitro qhia tau tias cov kua roj madecassic tau txo qis qib superoxide superoxide actions, thiab peroxyl radicals. Dab tsi ua rau madecassic acid txawv yog nws cov hauj lwm zoo nyob rau hauv ob qho kev tiv thaiv hydrophilic, muab cov kev tiv thaiv hydrophilic rau cov kev sib txawv ntawm cov oxidative.

Kev txhim kho ntawm Endogenous Antioxidant Tshuab

Dhau kev ua phem ncaj qha,madecassic acidUpregulates lub cev `s antioxidant tiv thaiv. Nws ua kom cov nrf2 txoj kev, ib tus tswv Regulator ntawm cov lus teb antioxidant. Thaum ua kom tiav, NRF2 khi rau antioxidant cov lus teb hauv DNA, colatorase enzymes, colalase dismutase, thiab heme oxygenase {}} 1. Kev tshawb fawb qhia tau tias kev kho cov pa roj sadecassic acid tau nce qib glutathione txog 40% piv rau kev tswj hwm. Qhov kev tsis ncaj ncees tsis ncaj ncees kev tiv thaiv kev tiv thaiv oxidative kev nyuaj siab los ntawm ntau txoj kev tiv thaiv thiab kev tiv thaiv ntev dua li cov tshuaj tiv thaiv kab mob antioxidies ib leeg.

Anti {- pi infl} Cov khoom siv rau antioxidant

Madecassic acid `s antioxidant cov nyiaj pab tau ua tiav los ntawm nws anti {} Cov khoom siv tau cuam tshuam rau ob qho chaw o thiab oxidative kev ntxhov siab. Nws tiv thaiv NF {-}}}}}}}}}}}}}}}}}}} Ib txoj kev tshawb fawb 2018 pom tias cov tshuaj madecassicicic acid txo qis thaum txo cov calorular Ros qib los ntawm kwv yees li 35%. Qhov kev txiav txim siab no ua rau lub voj voog uas txo qhov kev ntxhov siab, ua rau muaj kev ntxhov siab rau cov khoom siv roj ntsha, uas ntxiv rau cov mob oxidication thiab oxidative.

Potency thiab efficacy sib piv

Madecassic acid `s tshwj xeeb cov qauv kev coj ua pab txhawb rau qhov sib txawv ntawm antioxidant profile nrog ob peb qhov zoo. Hauv kev sib piv kev ntsuas ntsuas ntsuas ntsuas qhov muaj peev xwm (ORAC), madecassicic acid qhia pom ntau cov tshuaj tiv thaiv kab mob antioxidants. Kev tshawb nrhiav pom tias madecassic acid nthuav tawm ib tug lej raug kwv yees li 2.5 zaug siab dua li pab yaj, muaj zog flavonoid antioxidant. Lub Penaccylclic qauv tsim kev ruaj khov, tswj hwm nws cov kev ua tshuaj antioxidant nyob rau ntau lub dag zog. Tsis zoo li dej - Soluble antioxidants thiab lipid - Cov txheej txheem nplua nuj ntau dua. Tsis tas li ntawd, madecassic acid tswj hwm nws cov khoom antioxidant thoob plaws hauv cov dav dav ntau yam tsis muaj pro- Oxidant cuam tshuam.

Bioavailability thiab kev txiav txim siab ruaj khov

Madecassic acidPib cov txiaj ntsig ob qho tib si thiab cov kev sib tw hais txog Bioavailability thiab ruaj khov. Nws muaj cov ntaub ntawv me me ntawm kev tswj hwm thaum muab cov ncauj lus, nrog kev nqus cov nqi cuam tshuam los ntawm kev tsim qauv. Piv rau polyphenolic antioxidants xws li retveratrol thiab curcumin, uas feem ntau ua rau cov tshuaj tsis zoo, ua kom zoo dua cov tshuaj zoo nkauj dua li ntawm {2 {2} lub neej. Tshawb nrhiav siv lipid -} Cov khoom xa tawm tau pom tias nws cov xyoob bioavailability tau txhim kho txog 300% piv rau cov hau kev. Madecassic acid qhia tau zoo tshaj plaws ruaj khov nyob rau hauv ntau qhov kev ua si, khaws cia antioxidant kev ua tom qab raug cua sov kom sov, lub teeb, thiab cov pa. Txawm li cas los xij, cov txheej txheem sib xyaw ua ke thiab cov txheej txheem lim dej tsim nyog rau kev sib tw siab rau cov kev sib tw rau cov kev siv hluav taws xob loj.

Synergistic cuam tshuam nrog lwm qhov sib xyaw

Madecassic acid ua haujlwm synergistically nrog lwm cov tebchaw xyoob, muaj peev xwm ua kom muaj qhov cuam tshuam ntawm kev ua kom muaj kab mob antioxidant tag nrho. Kev tshawb fawb tau txheeb xyuas kev sib raug zoo ntawm kev sib txawv ntawm madecassic acid thiab lwm cov kev ua ke hauv cortella asiatica, xws li asiatic acid, asiaticoside, thiab madecassoside. Thaum ua ke nrog vitamin c, madecassic acid muab cov vitamin c yog qhov chaw ruaj khov thiab txuas ntxiv rau cov qauv antioxidant los ntawm txog 40% nyob rau hauv cov qauv vitro. Kev tshawb fawb hauv phytomedicine qhia tau tias cov qauv muaj cov qauv kev ua kom pom ntau dua rau UOK} inducted oxidative kev puas tsuaj tshaj li cov neeg sib txuas. Cov kev cuam tshuam no qhia tias cov kua qaub madecassicic acid yuav ua tau zoo tshaj plaws hauv kev ua tib zoo tsim kev sib txuas ua ke ntau dua li qhov sib txuas cais.

Dermatological Cov Kev Pab thiab Kev Siv Skinc

Madecassic acid`S Antioxidant cov khoom tau muab tso rau nws ua tus hwm nyiaj txiag kev lag luam. Cov kev tshawb fawb soj ntsuam qhia tias cov ntawv thov cov ntaub ntawv tseem ceeb tuaj yeem txo cov UVB zoo qauv uas muaj cov tsiaj oxygen li 68%, mitigating photoDamage thiab cov lus teb mob. Cov neeg tuaj yeem tshawb nrhiav cov koom nrog txo cov kab zoo, txhim kho cov tawv nqaij elasticity, thiab txhim kho kev muaj nuj nqi tom qab 8} 12 lub lis piam ntawm kev thov sib xws. Thaum dhau kev tawm tsam kev tiv thaiv kab mob antioxidant coj los, Madecassic kua qaub stimulates collagen synthesis thiab txhawb nqa kom muaj lub koom haum tsim nyog. Kev kawm hauv cov phau ntawv tshaj tawm thoob ntiaj teb ntawm cov qauv tshuaj pleev ib ce pom tias cov qauv uas muaj 0.2% madecassic acidopently nrawm nrawm thiab txo caws pliav. Cov txiaj ntsig no ua rau nws muaj nuj nqis rau kev daws teeb meem xws li Rosacea, eczema, thiab nws tau tawm los ua cov khoom siv tseem ceeb hauv kev tsim tawm los tiv thaiv cov tawv nqaij, thiab cov txheej txheem rhiab, thiab tom qab cov txheej txheem rov qab.

Neuroprotecive cuam tshuam los ntawm antioxidant mechanism

Lub neuroprotrotive muaj peev xwm ntawm madecassic acid tau tsim kev txaus siab rau kev txaus siab rau neuroscience. Lub hauv paus nruab nrab yog tshwj xeeb yog qhov tshwj xeeb rau oxidative kev nyuaj siab vim nws cov ntsiab lus oxygen ntawm Lipid cov ntsiab lus, thiab txwv antioxidant. Madecassic acid tuaj yeem hla ntshav -} barrier thiab tiv thaiv ntau yam neurotoxic thuam. Hauv kev sim ua qauv ntawm cov kev mob neurodegenerative tej yam kev mob, nws txo cov cim ntawm oxidative kev puas tsuaj hauv cov nqaij mos ntawm neuronal. Tshawb nrhiav hauv phau ntawv xov xwm ntawm Alzheimer `s tus kab mob pom tias muaj cov tsiaj muaj yees tuag los ntawm kwv yees li ntawm 56%, feem ntau los ntawm kev sib sau ua si oxygen. Nws kuj yog modulates ob peb signaling txoj hauv kev tseem ceeb rau neuronal ciaj sia thiab txhim kho mitochondrial muaj nuj nqi hauv neuronal hlwb. Cov txheej txheem no qhia tias cov kua roj acid tuaj yeem muaj txiaj ntsig rau kev txawj ntse, Neuroprotection, thiab muaj peev xwm ua ib qho kev sib tw hauv kev tswj hwm nurodegenerive.

Kev tiv thaiv kab mob plawv thiab kev noj qab haus huv metabolic

Madecassic acid`S Antioxidant cov khoom tau txuas ntxiv rau cov kev noj qab haus huv plawv thiab kev noj qab haus huv. Kev ntxhov siab oxidative ua lub luag haujlwm nruab nrab hauv atherosclerosis, kub siab, thiab ntau yam kev tsis sib haum metabolic. Kev tshawb fawb pom pom tias cov kua txiv madecassic tiv thaiv vascular endothelial hlwb los ntawm oxidive kev puas tsuaj, khaws cia nitric oxide bioavailability thiab tswj vasodilation zoo. Hauv cov qauv tsiaj ntawm bypertension, nws txo cov ntshav siab thiab txhim kho cov ntshav endothelial, sib cuam tshuam nrog cov cim kev nyuaj siab kawg li ntawm kev ua haujlwm. Feem ntau, madecassic acid inibles oxidation ntawm LDL cov roj cholesterol, kauj ruam tseem ceeb hauv atherosclerotic plaque. Kev kawm hauv phau ntawv xov xwm ntawm cov neeg saib xyuas cov hlab plawv pom tias nws txo ldl oxidation los ntawm kwv yees li 62% hauv ib qho qauv vitro. Los ntawm cov teeb meem metabolic, Madecassic Acid tau qhia txog kev txhim kho cov qauv insulin thiab cov tshuaj tsw qab, cov tshuaj insulin {{re} cov nqaij mos.

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Cov ntaub ntawv pov thawj rau madecassic acid `s antioxidant cov khoom yog sib sau thiab multifaceted thiab multifaceted. Los ntawm ncaj qha dawb radical txaus kom zoo antioxidant lub tshuab, nws muaj kev tiv thaiv kev tiv thaiv oxidative. Nws cov ntawv thov ncua los ntawm dermatology rau neuroprotection thiab kev noj qab haus huv plawv, ua rau nws muaj ntau yam sib txuas nrog lub peev xwm tseem ceeb. Raws li kev tshawb fawb txuas ntxiv mus,madecassic acidSawv raws li kev cog lus ntuj cog lus tsim nyog ntawm kev tshawb nrhiav kev tshawb nrhiav thiab kev lag luam lag luam.

Lonierhlerb yog ib tug neeg tsim khoom tsim hauv cov nroj tsuag cov khoom siv thiab cov tshuaj noj qab noj qab haus huv, kev ua haujlwm siab {{} tech cheeb tsam. Nrog ntau tshaj ib xyoo caum ntawm kev txawj ntse, peb muab cov kev pabcuam txuas ntawm R thiab D rau cov neeg siv khoom txhawb nqa. Peb GMP - Tau ntawv pov thawj 1500m² chaw lees paub zoo, thiab peb ua kom txhua yam khoom tau ntsib thoob ntiaj teb kev nyab xeeb cov qauv. Kev ntseeg siab los ntawm cov neeg tau txais 40 lub tebchaws, peb muab cov kev daws teeb meem rau kev lag luam xws li kev noj haus, dej noj qab haus huv, thiab tshuaj pleev ib ce. Kom paub meej ntxiv, hu rauinfo@lonierherb.com.

Ntawv Sawv cev

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2. Lee Jy, Kim Yj, Kim HJ, li al. (2022). Piv txwv li kev tsom xam ntawm kev ua haujlwm antioxidant ntawm madecassic acid thiab lwm yam ntuj sib xyaw ua ke los ntawm centella asiatica. Phau ntawv Journal ntawm cov khoom ntuj, 75 (4), 631-645.

3. Zhang L, Chen f, Tang X, li al. (2021). Madecassic Acid Inhibits LDL oxidation thiab txo cov quav atherosclerotic Plaqueent hauv Apoe {{4 {}} tsis muaj nas. Phau ntawv Journal of Cardiovasctric Lim, 68 (2), 123-135.

4. Singh S, Gautam a, Sharma a, li al. (2022). Kev txhim kho ntawm daim tawv nqaij teeb meem ntawm daim tawv nqaij ua haujlwm thiab collagen synthesis los ntawm cov duab kos npe ntawm madecassic acid: lub luag haujlwm ntawm cov antioxidant txoj kev taug. Cov ntawv xov xwm thoob ntiaj teb ntawm kev tshawb fawb kom zoo nkauj, 44 (1), 78-92.

5. LIU cm, Yang W, Chang YC, li al. (2023). Synergistic antioxidant thiab anti {{{{{incamassic acid ua ke nrog asiatic acid hauv Lipopolysaccharide- stimulated Macrocolages. PhyTomedicine, 96, 154082.

6. Ramachandran V, Saravanan R, SenhilRaja P. (2021). Antidiabetic thiab antioxidant cuam tshuam los ntawm madecassic acid nyob streptoozotocin-} kev siv ntshav qab zib thiab kho kev cuam tshuam. Biomedicine & Pharpacotherapy, 138, 111432.